Adaptive and nonadaptive responses to voluntary wheel running by mdx mice
- 24 September 2008
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 38 (4), 1290-1293
- https://doi.org/10.1002/mus.21141
Abstract
The purpose of this study was to determine the extent to which hindlimb muscles of mdx mice adapt to a voluntary endurance type of exercise. mdx and C57BL mice engaged in 8 weeks of wheel running or maintained normal cage activities. Beneficial adaptations that occurred in mdx mice included changes in muscle mass, fiber size, and fiber types based on myosin heavy chain (MHC) isoform expression. These adaptations occurred without increases in fiber central nuclei and embryonic MHC expression. An undesirable outcome, however, was that muscle mitochondrial enzyme activities did not improve with exercise in mdx mice as they did in C57BL mice. Cellular remodeling of dystrophic muscle following exercise has not been studied adequately. In this study we found that some, but not all, of the expected adaptations occurred in mdx mouse muscle. We must better understand these (non)adaptations in order to inform individuals with DMD about the benefits of exercise. Muscle Nerve 38: 1290–1303, 2008Keywords
This publication has 63 references indexed in Scilit:
- Elevated hypothalamic orexin signaling, sensitivity to orexin A, and spontaneous physical activity in obesity-resistant ratsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2006
- Muscle Fatigue during High-Intensity Exercise in ChildrenSports Medicine, 2006
- Muscle and joint elastic properties during elbow flexion in Duchenne muscular dystrophyThe Journal of Physiology, 2001
- Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exerciseFEBS Letters, 1995
- Dystrophin-dependent efficiency of metabolic pathways in mouse skeletal musclesCellular and Molecular Life Sciences, 1994
- Prevention of myonecrosis in mdx mice: Effect of immobilization by the local tetanus methodBrain & Development, 1992
- Three myosin heavy chain isoforms in type 2 skeletal muscle fibresJournal of Muscle Research and Cell Motility, 1989
- Functional regeneration in the hindlimb skeletal muscle of the mdx mouseJournal of Muscle Research and Cell Motility, 1988
- Significance of skeletal muscle oxidative enzyme enhancement with endurance trainingClinical Physiology and Functional Imaging, 1982
- Effects of low frequency electriclal stimulation on enzyme and isozyme patterns of dystrophic mouse muscleFEBS Letters, 1981