Fully Virulent Bacillus anthracis Does Not Require the Immunodominant Protein BclA for Pathogenesis
- 1 January 2007
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 75 (1), 508-511
- https://doi.org/10.1128/iai.01202-06
Abstract
The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant ( bclA ) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.Keywords
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