Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China
Open Access
- 16 September 2014
- journal article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 9 (9), e107181
- https://doi.org/10.1371/journal.pone.0107181
Abstract
Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality. We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included. A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027–1.109), presence of ARDS (OR, 2.676; 95%CI, 1.691–4.235), bloodstream infection (OR, 2.520; 95%CI, 1.142–5.564) and comorbidity of cancer (OR, 2.246; 95%CI, 1.141–4.420) were significantly associated with mortality. Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients.Keywords
This publication has 38 references indexed in Scilit:
- Clinical review: Ethics and end-of-life care for critically ill patients in ChinaCritical Care, 2013
- Outcomes in severe sepsis and patients with septic shock: Pathogen species and infection sites are not associated with mortality*Critical Care Medicine, 2011
- Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort studyBMJ, 2011
- Disease Progression in Hemodynamically Stable Patients Presenting to the Emergency Department With SepsisAcademic Emergency Medicine, 2010
- Clinical review: Critical care medicine in mainland ChinaCritical Care, 2010
- The epidemiology of, and risk factors for, mortality from severe sepsis and septic shock in a tertiary-care university hospital settingEpidemiology and Infection, 2009
- Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre studyCritical Care, 2008
- Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China*Critical Care Medicine, 2007
- Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in SepsisSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1992
- APACHE IICritical Care Medicine, 1985