Bowenoid lesions, Bowen's disease and keratoacanthomas in long-term PUVA-treated patients

Abstract

Four patients are described: 2 with histologically proven multiple foci of bowenoid lesions, 1 with bowenoid lesions and Bowen''s disease and 1 with 2 keratoacanthomas. Most lesions occurred in non-sun-exposed but photochemically treated areas of the body. These patients had received long-term PUVA [8 methoxypsoralin-long wavelength UV] treatment for their psoriasis. Two patients had a history of arsenic intake. The possible relationship of these epidermal lesions to light treatment is discussed.