Attenuated Stress Response to Acute Lipopolysaccharide Challenge and Ethanol Administration in Vasopressin V1b Receptor Knockout Mice
- 7 June 2007
- journal article
- Published by Wiley in Journal of Neuroendocrinology
- Vol. 19 (7), 543-551
- https://doi.org/10.1111/j.1365-2826.2007.01560.x
Abstract
The arginine vasopressin (Avp) 1b receptor (Avpr1b) present on anterior pituitary corticotrophs is involved in the stimulation of adrenocorticotrophic hormone (ACTH) secretion, especially during times of stress. Corticotrophin-releasing hormone (CRH) is considered the major ACTH secretagogue during acute stress whereas Avp appears to be the more dominant mediator of the hypothalamic-pituitary-adrenal (HPA) axis response during chronic stress situations. To investigate the role of the Avpr1b in the HPA axis response to acute stress, we measured ACTH and corticosterone (CORT) plasma levels in Avpr1b knockout (KO) mice and wild-type controls in response to bacterial lipopolysaccharide (LPS) challenge and ethanol (EtOH) administration. Mice deficient in Avpr1b had markedly compromised plasma ACTH and CORT responses to acute (30 min) LPS, but normal ACTH and CORT response to more extended exposure (4 h) to the immune system activator. The plasma ACTH and CORT levels stimulated by intoxicating, sedative doses of EtOH (3.2 and 4 g/kg) were significantly decreased in the Avpr1b KO mice compared to wild-type littermates. Significantly higher EtOH-induced plasma ACTH and CORT secretion was measured in female than in male Avpr1b wild-type mice. There were no differences in the blood alcohol levels following acute EtOH administration in Avpr1b KO or wild-type mice of either gender. Our results clearly suggest that Avpr1b plays a significant role in the HPA axis response to acute immune stress and EtOH intoxication.Keywords
This publication has 88 references indexed in Scilit:
- The Hypothalamic-Pituitary-Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b ReceptorsEndocrinology, 2007
- V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivityProceedings of the National Academy of Sciences of the United States of America, 2006
- The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisitedFrontiers in Neuroendocrinology, 2004
- Cannabis and alcohol – a close friendshipTrends in Pharmacological Sciences, 2003
- CRF Type I Receptor-Deficient Mice Exhibit a Pronounced Pituitary-Adrenal Response to Local InflammationEndocrinology, 1999
- Emergence of an Isolated Arginine Vasopressin (AVP) Response to Stress after Repeated Restraint: A Study of Both AVP and Corticotropin-Releasing Hormone Messenger Ribonucleic Acid (RNA) and Heteronuclear RNAEndocrinology, 1997
- Vasopressin and Oxytocin Receptors in the Central Nervous SystemCritical Reviews™ in Neurobiology, 1996
- Histamine- and Stress-Induced Secretion of ACTH and β-Endorphin: Involvement of Corticotropin-Releasing Hormone and VasopressinNeuroendocrinology, 1992
- Reflex control of magnocellular vasopressin and oxytocin secretionTrends in Neurosciences, 1991
- Ethanol increases plasma vasopressin shortly after intraperitoneal injection in ratsLife Sciences, 1985