Animal models for the preclinical evaluation of candidate influenza vaccines
- 9 January 2010
- journal article
- review article
- Published by Taylor & Francis Ltd in Expert Review of Vaccines
- Vol. 9 (1), 59-72
- https://doi.org/10.1586/erv.09.148
Abstract
At present, new influenza A (H1N1)2009 viruses of swine origin are responsible for the first influenza pandemic of the 21st Century. In addition, highly pathogenic avian influenza A/H5N1 viruses continue to cause outbreaks in poultry and, after zoonotic transmission, cause an ever-increasing number of human cases, of which 59% have a fatal clinical outcome. It is also feared that these viruses adapt to replication in humans and become transmissible from human to human. The development of effective vaccines against epidemic and (potentially) pandemic viruses is therefore considered a priority. In this review, we discuss animal models that are used for the preclinical evaluation of novel candidate influenza vaccines. In most cases, a tier of multiple animal models is used before the evaluation of vaccine candidates in clinical trials is considered. Commonly, vaccines are tested for safety and efficacy in mice, ferrets and/or macaques. The use of each of these species has its advantages and limitations, which are addressed here.Keywords
This publication has 120 references indexed in Scilit:
- Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and MiceScience, 2009
- Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in FerretsScience, 2009
- In vitro and in vivo characterization of new swine-origin H1N1 influenza virusesNature, 2009
- Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in HumansScience, 2009
- The cotton rat model of respiratory viral infectionsBiologicals, 2009
- Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virusProceedings of the National Academy of Sciences of the United States of America, 2009
- A Broadly Protective Vaccine against Globally Dispersed Clade 1 and Clade 2 H5N1 Influenza VirusesThe Journal of Infectious Diseases, 2008
- Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret modelProceedings of the National Academy of Sciences of the United States of America, 2006
- The guinea pig as a transmission model for human influenza virusesProceedings of the National Academy of Sciences of the United States of America, 2006
- A VIRUS OBTAINED FROM INFLUENZA PATIENTSThe Lancet, 1933