Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments
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Open Access
- 1 January 2008
- journal article
- Published by Springer Science and Business Media LLC in Genome Biology
- Vol. 9 (1), R7-22
- https://doi.org/10.1186/gb-2008-9-1-r7
Abstract
EVidenceModeler (EVM) is presented as an automated eukaryotic gene structure annotation tool that reports eukaryotic gene structures as a weighted consensus of all available evidence. EVM, when combined with the Program to Assemble Spliced Alignments (PASA), yields a comprehensive, configurable annotation system that predicts protein-coding genes and alternatively spliced isoforms. Our experiments on both rice and human genome sequences demonstrate that EVM produces automated gene structure annotation approaching the quality of manual curation.Keywords
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