Watershed Imaging Features and Clinical Vascular Injury in Cyclosporin A Neurotoxicity
- 1 November 1997
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Computer Assisted Tomography
- Vol. 21 (6), 872-880
- https://doi.org/10.1097/00004728-199711000-00005
Abstract
The purpose of our study was to assess whether the imaging and clinical features of cyclosporin A (CsA) neurotoxicity support a vascular“watershed” cause for the brain lesions observed. Fourteen patients receiving CsA after allogeneic bone marrow transplantation or with marrow aplastic disorders developed neurotoxicity and MR or CT imaging abnormalities. The locations of brain lesions were analyzed, and clinical features, in particular bone marrow transplant thrombotic microangiopathy (BMT-TM), were assessed. Sixty-six lesions had consistent locations in watershed zones between major cerebral vessels or their main branches, including the parietal area (19), occipital poles (18), frontoparietal junction (15), inferior temporooccipital junction (10), and cerebellum (3). BMT-TM was identified in 10 of 10 marrow transplant patients studied. Vascular injury, suggested from watershed location and BMT-TM, likely establishes the location of the brain lesions in CsA neurotoxicity. Secondary toxicity in these vulnerable regions may cause the white matter lesions.Keywords
This publication has 26 references indexed in Scilit:
- CYCLOSPORINE-ASSOCIATED CENTRAL NERVOUS SYSTEM TOXICITY AFTER RENAL TRANSPLANTATIONTransplantation, 1985
- Generalised epileptic fits in renal transplant recipients given cyclosporin A.BMJ, 1984
- ASSOCIATION BETWEEN CYCLOSPORIN NEUROTOXICITY AND HYPOMAGNESAEMIAThe Lancet, 1984
- ADULT RESPIRATORY DISTRESS SYNDROME AND CONVULSIONS ASSOCIATED WITH AMINISTRATION OF CYCLOSPORINE IN LIVER TRANSPLANT RECIPIENTSTransplantation, 1984
- Complex Visual Hallucinations and CyclosporineArchives of Neurology, 1984
- ANAPHYLACTIC REACTION TO INTRAVENOUS CYCLOSPORINThe Lancet, 1984
- KETOCONAZOLE AND CYCLOSPORINThe Lancet, 1982
- CYCLOSPORIN, METHYLPREDNISOLONE, AND CONVULSIONSThe Lancet, 1982
- CYCLOSPORIN A, METHYLPREDNISOLONE, AND CONVULSIONSThe Lancet, 1982
- HYPERTENSION AND CONVULSIONS IN CHILDREN RECEIVING CYCLOSPORIN AThe Lancet, 1982