Preventable adverse drug events in hospitalized patients
- 1 August 1997
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Critical Care Medicine
- Vol. 25 (8), 1289-1297
- https://doi.org/10.1097/00003246-199708000-00014
Abstract
To compare the frequency and preventability of adverse drug events and potential adverse drug events in intensive care units (ICUs) and non-ICUs. To evaluate systems factors involving the individual caregivers, care unit teams, and patients involved in each adverse drug event by comparing ICUs with non-ICUs and medical ICUs with surgical ICUs. Prospective cohort study. Participants included all 4,031 adult admissions to a stratified, random sample of 11 medical and surgical units in two tertiary care hospitals over a 6-month period. Units included two medical and three surgical ICUs and four medical and two surgical general care units. Two tertiary care hospitals: Eleven medical and surgical units, including two medical and three surgical ICUs. Adult admissions (n = 4,031). None. Rate of preventable adverse drug events and potential adverse drug events, length of stay, charges, costs, and measures of the unit's environment. The rate of preventable and potential adverse drug events was twice as high in ICUs compared with non-ICUs. However, when adjusted for the number of drugs ordered, there was no greater likelihood for preventable adverse drug events and potential adverse drug events to occur in ICUs than in non-ICUs. Preventable adverse drug events and potential adverse drug events occurred in units that functioned normally and involved caregivers who were working under reasonably normal circumstances, not at the extremes of workload, stress, or a difficult environment. (Crit Care Med 1997; 25:1289-1297)Keywords
This publication has 12 references indexed in Scilit:
- The Costs of Adverse Drug Events in Hospitalized PatientsJAMA, 1997
- Effects of Midazolam on Intracellular Calcium sup 2+ and Tension in Airway Smooth MusclesAnesthesiology, 1995
- Incidence of Adverse Drug Events and Potential Adverse Drug EventsJAMA, 1995
- Systems Analysis of Adverse Drug EventsJAMA, 1995
- Relationship between medication errors and adverse drug eventsJournal of General Internal Medicine, 1995
- A look into the nature and causes of human errors in the intensive care unitCritical Care Medicine, 1995
- Preventing Medical InjuryQRB - Quality Review Bulletin, 1993
- A new method of classifying prognostic comorbidity in longitudinal studies: Development and validationJournal of Chronic Diseases, 1987
- Therapeutic Intervention Scoring SystemCritical Care Medicine, 1983
- Therapeutic intervention scoring systemCritical Care Medicine, 1974