A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit
- 22 December 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Inflammopharmacology
- Vol. 20 (6), 307-314
- https://doi.org/10.1007/s10787-011-0107-3
Abstract
The anticancer effects of traditional Chinese medicine (TCM) have attracted the attention of the public vis-à-vis existing cancer therapies with various side effects. Lycium barbarum fruit, commonly known as Gou Qi Zi in China, is a potential anticancer agent/adjuvant. Its major active ingredients, L. barbarum polysaccharides (LBP), scopoletin and 2-O-β-d-glucopyranosyl-l-ascorbic acid (AA-2βG), are found to have apoptotic and antiproliferative effects on cancer cell lines. Moreover, LBP also contributes to body’s immunomodulatory effects and enhances effects of other cancer therapies. It is not known whether there are any undesirable effects. Further studies on its pharmacological mechanisms and toxicology could facilitate a safe usage of this TCM herb.Keywords
This publication has 67 references indexed in Scilit:
- Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stressFood and Chemical Toxicology, 2011
- Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositisRadiation Oncology, 2010
- Polysaccharides from Wolfberry Antagonizes Glutamate Excitotoxicity in Rat Cortical NeuronsCellular and Molecular Neurobiology, 2009
- Activation of macrophages by polysaccharide–protein complex from Lycium barbarum L.Phytotherapy Research, 2009
- Determination of carotenoids and their esters in fruits of Lycium barbarum Linnaeus by HPLC–DAD–APCI–MSJournal of Pharmaceutical and Biomedical Analysis, 2008
- Cumulative Incidence of Secondary Neoplasms as a First Event After Childhood Acute Lymphoblastic LeukemiaJAMA, 2007
- Scopoletin induces apoptosis in human promyeloleukemic cells, accompanied by activations of nuclear factor κB and caspase-3Life Sciences, 2005
- Effect of lycium barbarum polysaccharide on human hepatoma QGY7703 cells: Inhibition of proliferation and induction of apoptosisLife Sciences, 2005
- Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cellsFitoterapia, 2004
- Cancer immunoediting: from immunosurveillance to tumor escapeNature Immunology, 2002