Motor dyscontrol in narcolepsy: Rapid‐eye‐movement (REM) sleep without atonia and REM sleep behavior disorder
- 1 July 1992
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 32 (1), 3-10
- https://doi.org/10.1002/ana.410320103
Abstract
Narcolepsy involves abnormalities of rapid-eye-movement (REM) sleep, including a short latency to the onset of REM sleep, hypnagogic hallucinations, and sleep paralysis. In addition, persistence of muscle tone by electromyographic criteria or excessive muscle twitching during REM sleep or both have been reported in treated and untreated narcoleptic patients. We report that another previously described abnormality of REM sleep, REM sleep behavior disorder, may also be a symptom of narcolepsy. This disorder was found in 10 narcoleptic patients during routine clinical evaluations involving polysomnography and multiple sleep latency tests. During REM sleep, 7 additional narcoleptic patients displayed persistent muscle tone and/or excessive twitching, which we believe to be subclinical components of REM sleep behavior disorder. These 17 patients, diagnosed by established criteria for narcolepsy and for REM sleep behavior disorder, ranged in age from 8 to 74 years. Seventy-one percent were male. Narcolepsy and REM sleep behavior disorder most commonly emerged in tandem. In 3 patients, treatment of narcolepsy-cataplexy with stimulants and tricyclics either induced or exacerbated REM sleep behavior disorder.Keywords
This publication has 42 references indexed in Scilit:
- Shy-Drager Syndrome Presenting as a REM Behavioral DisorderJournal of Geriatric Psychiatry and Neurology, 1990
- The Atonia and Myoclonia of Active (REM) SleepAnnual Review of Psychology, 1990
- FAMILIAL PATTERNS OF NARCOLEPSYThe Lancet, 1989
- Sleep Disorders and Depression with Atypical FeaturesJournal of Clinical Psychopharmacology, 1989
- REM Sleep Behavioral DisordersEuropean Neurology, 1988
- Evolving concepts of sleep cycle generation: From brain centers to neuronal populationsBehavioral and Brain Sciences, 1986
- Subthreshold Excitatory Activity and Motoneuron Discharge During REM Periods of Active SleepScience, 1983
- Different behaviors during paradoxical sleep without atonia depend on pontine lesion siteBrain Research, 1982
- EVALUATION of SHORT-TERM and LONG-TERM TREATMENT of the NARCOLEPSY SYNDROME WITH CLOMIPRAMINE HYDROCHLORIDEActa Neurologica Scandinavica, 1976
- Changes During Weeks in Effects of Tricyclic Drugs on the Human Sleeping BrainThe British Journal of Psychiatry, 1972