COVID-19 Autopsies, Oklahoma, USA
Top Cited Papers
Open Access
- 1 June 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 153 (6), 725-733
- https://doi.org/10.1093/AJCP/AQAA062
Abstract
Objectives: To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals who died in Oklahoma (United States) in March 2020. Methods: Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs. Results: A 77-year-old obese man with a history of hypertension, splenectomy, and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils, or myocarditis. Conclusions: SARS-CoV-2 testing can be performed at autopsy. Autopsy findings such as diffuse alveolar damage and airway inflammation reflect true virus-related pathology; other findings represent superimposed or unrelated processes.This publication has 13 references indexed in Scilit:
- Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung CancerJournal of Thoracic Oncology, 2020
- Pathological findings of COVID-19 associated with acute respiratory distress syndromeThe Lancet Respiratory Medicine, 2020
- Three Emerging Coronaviruses in Two DecadesAmerican Journal of Clinical Pathology, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- Lung Biopsy Findings in Severe Pulmonary Illness Associated With E-Cigarette Use (Vaping) A Report of Eight CasesAmerican Journal of Clinical Pathology, 2020
- Pathology of Vaping-Associated Lung InjuryThe New England Journal of Medicine, 2019
- Acute Interstitial Pneumonia (AIP): Relationship to Hamman-Rich Syndrome, Diffuse Alveolar Damage (DAD), and Acute Respiratory Distress Syndrome (ARDS)Seminars in Respiratory and Critical Care Medicine, 2012
- Pathologic Findings in Novel Influenza A (H1N1) Virus (“Swine Flu”) InfectionAmerican Journal of Clinical Pathology, 2010
- Causes and Prognosis of Diffuse Alveolar Damage Diagnosed on Surgical Lung BiopsySocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2007
- Forensic Autopsy Performance StandardsAmerican Journal of Forensic Medicine & Pathology, 2006