Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

Abstract

• Human melanomas frequently contain PD-1-expressing cancer cell subpopulations • Inhibition of melanoma-PD-1 reduces tumor growth, independently of adaptive immunity • PD-1 overexpression and melanoma-PD-1:PD-L1 interactions promote tumor growth • Activation of the melanoma-PD-1 receptor modulates downstream mTOR signaling