The Cerebral Circulation and Metabolism in Arteriosclerotic and Hypertensive Cerebrovascular Disease

Abstract

RECENT studies on the pathogenesis of cerebrovascular accidents have emphasized the importance of either vasomotor changes in the cerebral vessels themselves or temporary inadequacy of the systemic circulation.¹, Although such functional alterations are probably significant in the causation of cerebrovascular accidents, the existence of structural changes in the cerebral vessels is generally believed to aggravate if not actually to provide the underlying basis of the vascular episode.³, n this regard it is of interest that a reduction in both cerebral blood flow⁵ and oxygen uptake⁶ has been found in elderly subjects even in the absence of symptoms of . . .