Letter from the editor: adenosine‐to‐inosine RNA editing in Alu repeats in the human genome

Abstract

This report provides evidence that loss of the SCF^Slimb E3 ubiquitin ligase complex as well as hyperactivation of Akt lead to neuroblast overgrowth and defects in asymmetric cell division. Slimb, the F‐box protein of the SCF complex, associates with Akt in a protein complex, and SCF^Slimb acts through SAK and Akt to inhibit neuroblast overgrowth. During mitosis, Haspin phosphorylates histone H3 at Thr 3 to recruit the chromosomal passenger complex (CPC). This study shows that this event is controlled by Plk1‐mediated phosphorylation of Haspin, which is required for H3 modification in early mitosis and thus for appropriate CPC recruitment. Using smFRET and small angle X‐ray scattering (SAXS) experiments, we investigate the influence of structured mRNA on the conformational dynamics of the ribosome. We observe that upon interaction with structured elements, the small subunit is driven into a hyper‐rotated state and the frequency of intersubunit motion is reduced.