Changes in Corneal Endothelial Cell after Ahmed Glaucoma Valve Implantation and Trabeculectomy: 1-Year Follow-up
Open Access
- 1 January 2016
- journal article
- Published by Korean Ophthalmological Society in Korean Journal of Ophthalmology
- Vol. 30 (6), 416-425
- https://doi.org/10.3341/kjo.2016.30.6.416
Abstract
To compare changes in corneal endothelial cell density (CECD) after Ahmed glaucoma valve (AGV) implantation and trabeculectomy. Changes in corneal endothelium in patients that underwent AGV implantation or trabeculectomy were prospectively evaluated. Corneal specular microscopy was performed at the central cornea using a non-contact specular microscope before surgery and 6 months and 12 months after surgery. The CECD, hexagonality of the endothelial cells, and the coefficient of variation of the cell areas were compared between the two groups. Forty eyes of 40 patients with AGV implantation and 28 eyes of 28 patients with trabeculectomy were studied. Intraocular pressure in the AGV implantation group was significantly higher than that in the trabeculectomy group (p < 0.001), but there was no significant difference in other clinical variables between the two groups. In the AGV implantation group, the mean CECD significantly decreased by 9.4% at 6 months and 12.3% at 12 months compared with baseline values (both, p < 0.001), while it decreased by 1.9% at 6 months and 3.2% at 12 months in the trabeculectomy group (p = 0.027 and p = 0.015, respectively). The changes at 6 months and 12 months in the AGV implantation group were significantly higher than those in the trabeculectomy group (p = 0.030 and p = 0.027, respectively). In the AGV implantation group, there was a significant decrease in the CECD between baseline and 6 months and between 6 months and 12 months (p < 0.001 and p = 0.005, respectively). However, in the trabeculectomy group, a significant decrease was observed only between baseline and 6 months (p = 0.027). Both the AGV implantation group and the trabeculectomy group showed statistically significant decreases in the CECD 1 year after surgery. The decrease in CECD in the AVG implantation group was greater and persisted longer than that in the trabeculectomy group.Keywords
This publication has 34 references indexed in Scilit:
- The Effect of an Ahmed Glaucoma Valve Implant on Corneal Endothelial Cell Density in Children With Glaucoma Secondary to UveitisAmerican Journal of Ophthalmology, 2013
- Postoperative Complications in the Tube Versus Trabeculectomy (TVT) Study During Five Years of Follow-upAmerican Journal of Ophthalmology, 2012
- Corneal Endothelial Cell Changes After Ahmed ™ Valve and Molteno ™ Glaucoma ImplantsOphthalmic Surgery, Lasers and Imaging Retina, 2011
- Corneal Endothelial Cell Loss After Mitomycin C-augmented TrabeculectomyJournal of Glaucoma, 2008
- Changes in corneal endothelial cell density and morphology after Ahmed glaucoma valve implantation during the first year of follow upClinical & Experimental Ophthalmology, 2008
- Corneal Endothelial Cell Changes After Trabeculectomy and Deep SclerectomyJournal of Glaucoma, 2007
- Effect of cataract surgery on the corneal endothelium*1Modern phacoemulsification compared with extracapsular cataract surgeryOphthalmology, 2004
- Follow-up of the original cohort with the Ahmed glaucoma valve implantAmerican Journal of Ophthalmology, 1999
- The corneal endotheliumEye, 1990
- Trabeculectomy with Simultaneous Topical Application of Mitomycin-C in Refractory GlaucomaJournal of Ocular Pharmacology and Therapeutics, 1990