The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets
- 15 March 2000
- journal article
- Published by Elsevier BV in Neuropharmacology
- Vol. 39 (4), 652-663
- https://doi.org/10.1016/s0028-3908(99)00172-0
Abstract
No abstract availableKeywords
This publication has 32 references indexed in Scilit:
- The site of the anti-emetic action of tachykinin NK1 receptor antagonists may exist in the medullary area adjacent to the semicompact part of the nucleus ambiguusBrain Research, 1999
- The tachykinin NK1 receptor antagonist GR205171 abolishes the retching activity of neurons comprising the central pattern generator for vomiting in dogsNeuroscience Research, 1999
- GR205171: A novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activityRegulatory Peptides, 1996
- The pharmacology of the emetic response to upper gastrointestinal tract stimulation in Suncus murinusEuropean Journal of Pharmacology, 1996
- Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferretsEuropean Journal of Pharmacology, 1996
- The pharmacology of GR203040, a novel, potent and selective non‐peptide tachykinin NK1 receptor antagonistBritish Journal of Pharmacology, 1995
- The broad‐spectrum anti‐emetic activity of the novel non‐peptide tachykinin NK1 receptor antagonist GR203040British Journal of Pharmacology, 1995
- Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferretsEuropean Journal of Pharmacology, 1993
- Ondansetron Compared with High-Dose Metoclopramide in Prophylaxis of Acute and Delayed Cisplatin-Induced Nausea and VomitingAnnals of Internal Medicine, 1990
- Pharmacological properties of GR38032F, a novel antagonist at 5‐HT3 receptorsBritish Journal of Pharmacology, 1988