Urinary Catecholamine Metabolites during Behavioral Changes in a Patient with Manic-Depressive Cycles
- 19 January 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4070), 300-302
- https://doi.org/10.1126/science.179.4070.300
Abstract
3-Methoxy-4-hydroxyphenylglycol and normetanephrine were analyzed in daily urine specimens of a patient with manic-depressive cycles who was studied longitudinally. The quantities of these catecholamine metabolites excreted into urine were decreased during periods of depression as compared with periods of mania. Urinary excretion of 3-methoxy-4-hydroxyphenylglycol varied cyclically with a period length of approximately 20 days. Changes in this metabolite, and perhaps in normetanephrine, preceded the affective and behavioral shifts.Keywords
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