Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
Top Cited Papers
- 18 December 2015
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Endocrinology
- Vol. 12 (3), 144-153
- https://doi.org/10.1038/nrendo.2015.216
Abstract
Reported rises in the prevalence of diabetic cardiomyopathy among developed nations have occurred in parallel with increased rates of obesity, insulin resistance and hyperinsulinaemia Insulin resistance and/or hyperinsulinaemia seem to underpin the development of diabetic cardiomyopathy, which is initially characterized by diastolic dysfunction in the absence of coronary artery disease and hypertension Pathophysiological mechanisms include impaired insulin signalling, cardiac mitochondrial dysfunction, endoplasmic reticulum stress, impaired autophagy, impaired myocardial calcium handling, abnormal coronary microcirculation, inappropriate neurohumoral activation and maladaptive immune responses Insulin resistance, or hyperinsulinaemia, independently predisposes to the development of diabetic cardiomyopathy and targeting insulin resistance or hyperinsulinaemia could be a potential therapeutic strategy to prevent the development of diabetic cardiomyopathyKeywords
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