Congenital talipes equinovarus: an epidemiological study in Sicily
Open Access
- 11 April 2012
- journal article
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 83 (3), 294-298
- https://doi.org/10.3109/17453674.2012.678797
Abstract
Congenital talipes equinovarus (clubfoot) can present in 2 forms: “syndromic”, in which other malformations exist, and the more common “idiopathic” form, where there are no other associated malformations. We analyzed the epidemiology of congenital talipes equinovarus in the Sicilian population, looking for potential etiological factors. Among the 801,324 live births recorded between January 1991 and December 2004, 827 cases were registered (560 males; M/F sex ratio: 2.1). Control infants were randomly selected from a historical cohort of live births without any major congenital malformations. A positive family history of clubfoot, gender, and maternal smoking were found to be risk factors for clubfoot. Patients with clubfoot were born most frequently during the period January–March. No association was found between clubfoot and reproductive history, peri-conceptional maternal drug exposure, maternal education, or ethnicity. Our findings emphasize the importance of birth defects surveillance programs and their usefulness in investigating potential risk factors.Keywords
This publication has 34 references indexed in Scilit:
- Perinatal outcome of prenatally diagnosed congenital talipes equinovarusPrenatal Diagnosis, 2011
- Update on Clubfoot: Etiology and TreatmentClinical Orthopaedics and Related Research, 2009
- Incidence of congenital clubfoot in SwedenActa Orthopaedica, 2006
- A South Australian population‐based study of congenital talipes equinovarusPaediatric and Perinatal Epidemiology, 2005
- Risk factors for isolated talipes equinovarus in Western Australia, 1980-1994Paediatric and Perinatal Epidemiology, 2005
- Idiopathic talipes equinovarus (ITEV) (clubfeet) in TexasAmerican Journal of Medical Genetics Part A, 2005
- Seasonal Distribution of Idiopathic Congenital Talipes Equinovarus in ScotlandJournal of Pediatric Orthopaedics B, 2002
- Biostatistical AnalysisEcology, 1996
- Incidence of congenital clubfoot in SwedenActa Orthopaedica, 1992
- A Higher Incidence of Congenital Structural Talipes Equinovarus in GipsiesHuman Heredity, 1983