Coupling of Human Circadian and Cell Cycles by the Timeless Protein
Open Access
- 1 April 2005
- journal article
- research article
- Published by Informa UK Limited in Molecular and Cellular Biology
- Vol. 25 (8), 3109-3116
- https://doi.org/10.1128/mcb.25.8.3109-3116.2005
Abstract
The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.Keywords
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