Multiple IgG4‐related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum
- 13 August 2009
- journal article
- case report
- Published by Wiley in Pathology International
- Vol. 59 (9), 670-675
- https://doi.org/10.1111/j.1440-1827.2009.02425.x
Abstract
IgG4-related sclerosing disease is recognized as a distinct clinicopathological entity. It is well known that this disease can occur in the salivary, lacrimal and pituitary glands, in the head and neck region. The nasal cavity is an extremely rare site of involvement of IgG4-related sclerosing disease. Herein is reported a case of multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum. A 73-year-old Japanese man presented with nasal obstruction and tumors of the right maxillary sinus and parotid gland were detected, after which resections of these tumors were performed. One year after the last surgery, he noted swelling of the nasal septum, and the tumor was resected. These three tumors had similar histopathology, such as conspicuous fibrosclerotic changes with dense lymphoplasmacytic infiltration and occasional obliterative phlebitis. Immunohistochemistry indicated abundant IgG4-positive plasma cell infiltration and high ratios of IgG4-positive/IgG-positive plasma cells (>70%) in all three lesions. The diagnosis of multiple IgG4-related sclerosing lesions was made. The present case suggests that IgG4-related sclerosing lesion can occur in the maxillary sinus and nasal septum, and represents an extension of the spectrum of IgG4-related sclerosing disease.Keywords
This publication has 27 references indexed in Scilit:
- IgG4‐related inflammatory aneurysm of the aortic archPathology International, 2009
- Down‐Regulation of Carbonic Anhydrase Isoenzymes in Nasal PolypsThe Laryngoscope, 2008
- Recent advances in autoimmune pancreatitis: concept, diagnosis, and pathogenesisThe Esophagus, 2008
- IgG4-related sclerosing diseaseWorld Journal of Gastroenterology, 2008
- Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitisHepatology, 2007
- IgG4-related Sclerosing Cholangitis With and Without Hepatic Inflammatory Pseudotumor, and Sclerosing Pancreatitis-associated Sclerosing CholangitisThe American Journal of Surgical Pathology, 2004
- High Serum IgG4 Concentrations in Patients with Sclerosing PancreatitisNew England Journal of Medicine, 2001
- Immunohistochemical detection of lactoferrin in different human glandular tissues with special reference to the exocrine pancreasActa Histochemica, 1993
- Immunohistochemical Localization of Human Carbonic Anhydrase IsozymesAnnals of the New York Academy of Sciences, 1984
- Tumefactive fibro-inflammatory lesions of the head and neckThe American Journal of Surgical Pathology, 1983