Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea
- 1 September 2009
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1173 (1), 675-682
- https://doi.org/10.1111/j.1749-6632.2009.04671.x
Abstract
The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, toxoplsmosis, Epstein-Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti-double-stranded (ds)DNA, anti-chromatin, anti-ribonucleoprotein (RNP), anti-SSB, anti-SSA, anti-Scl-70, anti-Smith, anti-centromer, anti-SmRNP, anti-Jo-1, and anti-ribosomal-P] using the Bio-Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0-6% of controls (P < 0.0001). Anti-dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (<10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM-antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross-react with the pathogenic anti-dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies.Keywords
This publication has 45 references indexed in Scilit:
- Oxidation of LDL and its clinical implicationAutoimmunity Reviews, 2008
- Autoimmunity in atherosclerosis: a protective response losing control?Journal of Internal Medicine, 2008
- Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New GuineaNutrition & Metabolism, 2007
- The fine-tuning of anti-oxidized low-density lipoprotein antibodies in cardiovascular disease and thrombosisThrombosis and Haemostasis, 2007
- Inflammation and Accelerated Atherosclerosis: Basic MechanismsRheumatic Disease Clinics of North America, 2005
- Intravenous Immunoglobulin and AtherosclerosisClinical Reviews in Allergy & Immunology, 2005
- Are Anti–Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective?Circulation, 2004
- Determinants of serum triglycerides and high‐density lipoprotein cholesterol in traditional Trobriand Islanders: the Kitava StudyScandinavian Journal of Clinical and Laboratory Investigation, 2003
- Innate and Adaptive Immunity in the Pathogenesis of AtherosclerosisCirculation Research, 2002
- Apparent absence of stroke and ischaemic heart disease in a traditional Melanesian island: a clinical study in KitavaJournal of Internal Medicine, 1993