SelSim: a program to simulate population genetic data with natural selection and recombination

Abstract

Summary: SelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection. Availability:http://www.stats.ox.ac.uk/mathgen/software.html Supplementary information:http://www.stats.ox.ac.uk/mathgen/software.html