The effects of bisphosphonates on jaw bone remodeling, tissue properties, and extraction healing
- 27 January 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Odontology
- Vol. 99 (1), 8-17
- https://doi.org/10.1007/s10266-010-0153-0
Abstract
Bisphosphonate effects on the skeleton have been studied in the context of a broad range of disciplines, including endocrinology, orthopedics, oncology, and dentistry. The emergence of osteonecrosis of the jaw as a rare but serious side effect of bisphosphonate treatment has stimulated interest in understanding how this drug class affects the oral skeleton. This review focuses on recent work describing how bisphosphonates affect bone remodeling, tissue properties, and postsurgical healing in the oral cavity.Keywords
This publication has 74 references indexed in Scilit:
- A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in miceBone, 2011
- Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw–like disease in miceJournal of Bone and Mineral Research, 2010
- Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in ratsJournal of Bone and Mineral Research, 2010
- Compromised osseous healing of dental extraction sites in zoledronic acid-treated dogsOsteoporosis International, 2010
- Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on BoneCalcified Tissue International, 2009
- Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronateOsteoporosis International, 2008
- Alendronate Reduces Bone Toughness of Ribs without Significantly Increasing Microdamage Accumulation in Dogs Following 3 Years of Daily TreatmentCalcified Tissue International, 2008
- Mandible Matrix Necrosis in Beagle Dogs After 3 Years of Daily Oral Bisphosphonate TreatmentJournal of Oral and Maxillofacial Surgery, 2008
- Effectiveness of bisphosphonates on nonvertebral and hip fractures in the first year of therapy: The risedronate and alendronate (REAL) cohort studyOsteoporosis International, 2006
- Remodeling dynamics in the alveolar process in skeletally mature dogsThe Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2006