Mechanism of the Interaction of Superoxide Ion and Ascorbate with Anthracycline Antibiotics
- 1 January 1987
- journal article
- Published by Informa UK Limited in Free Radical Research Communications
- Vol. 3 (1-5), 141-150
- https://doi.org/10.3109/10715768709069779
Abstract
The interaction of superoxide ion and ascorbate anion with anthracycline antibiotics (adriamycin and aclacinimycin A) as well as with their Fe3+ complexes has been studied in aprotic and protic media. It was found that both superoxide and ascorbate reduce anthracyclines to deoxyaglycons via a one-electron transfer mechanism under all conditions studied. The reaction of ascorbate anion with adriamycin and aclacinomycin A in aqueous solution proceeded only in the presence of Fe3+ ions; it is supposed that an active catalytic species was Fe3+ adriamycin. It is also supposed that the reduction of anthracycline antibiotics by O,7 and ascorbate in cells may increase their anticancer effect.Keywords
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