Sub-national TB prevalence surveys in India, 2006-2012: Results of uniformly conducted data analysis
Open Access
- 22 February 2019
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 14 (2), e0212264
- https://doi.org/10.1371/journal.pone.0212264
Abstract
Community based tuberculosis (TB) prevalence surveys in ten sites across India during 2006–2012 To re-analyze data of recent sub-national surveys using uniform statistical methods and obtain a pooled national level estimate of prevalence of TB. Individuals ≥15 years old were screened by interview for symptoms suggestive of Pulmonary TB (PTB) and history of anti-TB treatment; additional screening by chest radiography was undertaken in five sites. Two sputum specimens were examined by smear and culture among Screen-positives. Prevalence in each site was estimated after imputing missing values to correct for bias introduced by incompleteness of data. In five sites, prevalence was corrected for non-screening by radiography. Pooled prevalence of bacteriologically positive PTB was estimated using Random Effects Model after excluding data from one site. Overall prevalence of TB (all ages, all types) was estimated by adjusting for extra-pulmonary TB and Pediatric TB. Of 769290 individuals registered, 715989 were screened by interview and 294532 also by radiography. Sputum specimen were examined from 50 852 individuals. Estimated prevalence of smear positive, culture positive and bacteriologically positive PTB varied between 108.4–428.1, 147.9–429.8 and 170.8–528.4 per 100000 populations in different sites. Pooled estimate of prevalence of bacteriologically positive PTB was 350.0 (260.7, 439.0). Overall prevalence of TB was estimated at 300.7 (223.7–377.5) in 2009, the mid-year of surveys. Prevalence was significantly higher in rural compared to urban areas. TB burden continues to be high in India suggesting further strengthening of TB control activities.Keywords
This publication has 16 references indexed in Scilit:
- Prevalence and Risk Factors for Adult Pulmonary Tuberculosis in a Metropolitan City of South IndiaPLOS ONE, 2015
- Prevalence of tuberculosis in Faridabad district, Haryana State, IndiaIndian Journal Of Medical Research, 2015
- Prevalence of pulmonary tuberculosis in Wardha district of Maharashtra, Central IndiaJournal of Epidemiology and Global Health, 2015
- Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling studyThe Lancet. Global Health, 2014
- Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013The Lancet, 2014
- Prevalence of Pulmonary Tuberculosis - A Baseline Survey In Central IndiaPLOS ONE, 2012
- Screening Strategies for Tuberculosis Prevalence Surveys: The Value of Chest Radiography and SymptomsPLOS ONE, 2012
- Tuberculosis epidemiology in India: a review.2005
- ESTIMATION OF PREVALENCE OF BACILLARY TUBERCULOSIS ON BASIS OF CHEST X-RAY AND-OR SYMPTOMATIC SCREENING1976
- Tuberculosis in a rural population of South India: a five-year epidemiological study.1974