T‐cell populations in the pig intestinal lamina propria: memory cells with unusual phenotypic characteristics
Open Access
- 1 January 1999
- journal article
- research article
- Published by Wiley in Immunology
- Vol. 96 (1), 66-73
- https://doi.org/10.1046/j.1365-2567.1999.00658.x
Abstract
We have previously presented evidence of a highly organized and compartmentalized structure of the small intestinal lamina propria of the pig. In this study, we conducted a detailed analysis of the T-cell populations found at this site, and compared these T cells with cell populations found in other tissue sites and the periphery. We showed that the CD4+ and CD8+ T-cell populations found in the pig gut are of memory phenotype, defined by CD45 isoform expression, but show few signs of recent activation. They show a high degree of phenotypic and therefore presumably functional homogeneity. Both CD4- and CD8-positive cells show strong parallels in the patterns of surface molecule expression, suggesting similar pressures on differentiation. The unique combination of surface molecules found on lamina propria T cells is found only infrequently on cells in other lymphoid sites.Keywords
This publication has 33 references indexed in Scilit:
- Activation signals regulate heat shock transcription factor 1 in human B lymphocytesJournal of Cellular Physiology, 1997
- Antigen presenting cells in the porcine gutVeterinary Immunology and Immunopathology, 1996
- CD4+CD45RA+T cells from adults respond to recall antigens after CD28 ligationInternational Immunology, 1996
- Phenotypic classification of porcine lymphocyte subpopulations in blood and lymphoid tissuesImmunology, 1996
- Effect of early weaning on the development of immune cells in the pig small intestineVeterinary Immunology and Immunopathology, 1995
- Analysis of mAb reactive with the porcine SWC1Veterinary Immunology and Immunopathology, 1994
- Porcine peripheral blood CD4+/CD8+ dual expressing T-cellsVeterinary Immunology and Immunopathology, 1994
- The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosisEuropean Journal of Immunology, 1994
- Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytesEuropean Journal of Immunology, 1993
- Interconversion of CD45R subsets of CD4 T cells in vivoNature, 1990