Coregulator-Related Diseases
- 1 January 2004
- journal article
- research article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 43 (5), 368-373
- https://doi.org/10.2169/internalmedicine.43.368
Abstract
Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new "coregulator disease" concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked dementia and hypothyroidism syndrome. In addition, coregulators are thought to be closely associated with the pathogenesis of several diseases such as hormone-dependent cancers and leukemia. Based on these observations, the clinical disorders associated with some coregulator abnormalities were reviewed.Keywords
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