Physical approaches to biomaterial design
Top Cited Papers
- 1 January 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Materials
- Vol. 8 (1), 15-23
- https://doi.org/10.1038/nmat2344
Abstract
The development of biomaterials for drug delivery, tissue engineering and medical diagnostics has traditionally been based on new chemistries. However, there is growing recognition that the physical as well as the chemical properties of materials can regulate biological responses. Here, we review this transition with regard to selected physical properties including size, shape, mechanical properties, surface texture and compartmentalization. In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties.Keywords
This publication has 134 references indexed in Scilit:
- Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in miceCancer Letters, 2008
- Noninvasive Raman Spectroscopy in Living Mice for Evaluation of Tumor Targeting with Carbon NanotubesNano Letters, 2008
- Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted CarriersMolecular Therapy, 2008
- Factors Affecting the Clearance and Biodistribution of Polymeric NanoparticlesMolecular Pharmaceutics, 2008
- Shape Induced Inhibition of Phagocytosis of Polymer ParticlesPharmaceutical Research, 2008
- Role of Particle Size in Phagocytosis of Polymeric MicrospheresPharmaceutical Research, 2008
- Spatiotemporal control over growth factor signaling for therapeutic neovascularizationAdvanced Drug Delivery Reviews, 2007
- Cellular and multicellular form and functionAdvanced Drug Delivery Reviews, 2007
- Nanofabricated particles for engineered drug therapies: A preliminary biodistribution study of PRINT™ nanoparticlesJournal of Controlled Release, 2007
- Nanoscale Cell Adhesion Ligand Presentation Regulates Nonviral Gene Delivery and ExpressionNano Letters, 2006