The elevated preoperative neutrophil-to-lymphocyte ratio predicts poor prognosis in intrahepatic cholangiocarcinoma patients undergoing hepatectomy
- 12 February 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Tumor Biology
- Vol. 36 (7), 5283-5289
- https://doi.org/10.1007/s13277-015-3188-6
Abstract
A high preoperative peripheral blood neutrophil-to-lymphocyte ratio (NLR) has been reported to be a predictor of poor survival in patients with various cancers. The aim of this study was to evaluate the predictive significance of the NLR in patients undergoing hepatectomy for intrahepatic cholangiocarcinoma (ICC). From 2005 to 2011, 322 patients who underwent hepatectomy for ICC were enrolled in this retrospective study. Clinicopathological parameters, including NLR, were evaluated to identify predictors of overall and recurrence-free survival after hepatectomy. The best cutoff for NLR was 2.49, and 177 of 322 patients (54.9 %) had an NLR ≥ 2.49. The 5-year survival rate after hepatectomy was 51.1 % in patients with NLR < 2.49 and 24.8 % in those with NLR ≥ 2.49 (P = 0.0001). Univariate analyses revealed that NLR was significantly associated with recurrence-free survival (RFS) and overall survival (OS; both P < 0.05). Multivariable analyses revealed that elevated NLR independently predicted poorer OS (P = 0.003, hazard ratio [HR] = 1.600). In summary, our results indicate that elevated NLR is a promising independent predictor of poor survival after hepatectomy in patients with ICC.This publication has 55 references indexed in Scilit:
- Association of neutrophil–lymphocyte ratio with impaired aortic elasticity in newly diagnosed and never-treated hypertensive patientsBlood Pressure Monitoring, 2015
- A derived neutrophil to lymphocyte ratio predicts survival in patients with cancerBritish Journal of Cancer, 2012
- A novel and validated prognostic index in hepatocellular carcinoma: The inflammation based index (IBI)Journal of Hepatology, 2012
- Role of IL-17A in Neutrophil Recruitment and Hepatic Injury after Warm Ischemia–Reperfusion MicePublished by The American Association of Immunologists ,2011
- Negative Impact of Neutrophil-Lymphocyte Ratio on Outcome After Liver Transplantation for Hepatocellular CarcinomaAnnals of Surgery, 2009
- Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After ResectionJournal of Clinical Oncology, 2007
- Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cellsNature Immunology, 2007
- Systemic inflammatory response predicts survival following curative resection of colorectal cancerBritish Journal of Surgery, 2003
- Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factorNature Medicine, 2002
- A Western surgical experience of peripheral cholangiocarcinomaBritish Journal of Surgery, 1996