Inhibition of fibrin monomer polymerisation by myeloma immunoglobulin.
Open Access
- 1 March 1994
- journal article
- case report
- Published by BMJ in Journal of Clinical Pathology
- Vol. 47 (3), 266-268
- https://doi.org/10.1136/jcp.47.3.266
Abstract
Myelomatosis was diagnosed in a 64 year old man on the basis of a serum paraprotein band (type IgG lambda, 42 g/l), plasma cell infiltration of bone marrow, and multiple lytic lesions evident on skull x ray picture. Blood specimens taken into plain glass tubes showed bulky gelatinous clot formation with minimal clot retraction. Coagulation tests were significantly abnormal with an increase in thrombin time, prothrombin time, and reptilase time. The possibility that the paraprotein was interfering with fibrin production was investigated. The rate of fibrin monomer polymerisation (measured turbidometrically) was reduced in patient plasma compared with control plasma. Although purified fibrin monomer prepared from the patient's fibrinogen polymerised normally, the addition of purified paraprotein caused a dose dependent reduction in the rate of polymerisation. These results suggest that the paraprotein was impairing fibrin formation by inhibiting fibrin monomer polymerisation. After chemotherapy the paraprotein concentration decreased and the coagulation results returned to normal.Keywords
This publication has 9 references indexed in Scilit:
- The Normal and Morbid Biology of FibrinogenThe American Journal of Medicine, 1989
- Hereditary dysfibrinogenemia.1985
- Hereditary dysfibrinogenemia.Clinical Chemistry, 1985
- A Naturally Occurring Antibody That Inhibits Fibrin PolymerizationThe New England Journal of Medicine, 1981
- Dysfibrinogenemia Associated with Liver DiseaseJCI Insight, 1977
- Antibody activity of human myeloma globulins.1973
- Inhibition of Fibrin Monomer Polymerization by Lambda Myeloma GlobulinsBlood, 1972
- Fibrinogen Bethesda: a congenital dysfibrinogenemia with delayed fibrinopeptide releaseJCI Insight, 1971
- Inhibition of Conversion of Fibrinogen to Fibrin by Abnormal Proteins in Multiple MyelomaAmerican Journal of Clinical Pathology, 1955