Needle puncture injury of the rat intervertebral disc affects torsional and compressive biomechanics differently
- 11 June 2010
- journal article
- Published by Springer Science and Business Media LLC in European Spine Journal
- Vol. 19 (12), 2110-2116
- https://doi.org/10.1007/s00586-010-1473-z
Abstract
Needle puncture is a common method of inducing intervertebral disc (IVD) degeneration in small animal models and may have some similarities to IVD injury conditions such as herniation. Yet, the influence of puncture injuries on IVD biomechanics is not well understood. This study quantified the acute effects of anular injury on the biomechanics of rat caudal IVDs in compression and torsion following puncture with 30, 25 and 21 G needles. In compression, puncture injury reduced elastic stiffness by 20% for all needle sizes, but differences between control and punctured discs did not remain after compressive overload. In contrast, torsional parameters associated with anular fiber tension were affected proportionally with needle size. We conclude that IVD injuries that penetrate through the thickness of the annulus affect IVD biomechanics through different mechanisms for compression and torsion. Anular injuries affect torsional properties in a manner directly related to the amount of fiber disruption and compressive properties in a manner that affects pressurization.Keywords
This publication has 34 references indexed in Scilit:
- Time-Dependent Compressive Deformation of the Ageing SpineSpine, 2010
- Localized Intervertebral Disc Injury Leads to Organ Level Changes in Structure, Cellularity, and BiosynthesisCellular and Molecular Bioengineering, 2009
- Rat disc torsional mechanics: effect of lumbar and caudal levels and axial compression loadThe Spine Journal, 2009
- ISSLS Prize Winner: Microstructure and Mechanical Disruption of the Lumbar Disc AnnulusSpine, 2008
- Frequency-Dependent Behavior of the Intervertebral Disc in Response to Each of Six Degree of Freedom Dynamic LoadingSpine, 2008
- Needle Puncture Injury Affects Intervertebral Disc Mechanics and Biology in an Organ Culture ModelSpine, 2008
- Different Effects of Static Versus Cyclic Compressive Loading on Rat Intervertebral Disc Height and Water Loss In VitroSpine, 2007
- Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discsThe Spine Journal, 2006
- Online Article AbstractsSpine, 2005
- Three-Dimensional X-ray Analysis of Normal Movement in the Lumbar SpineSpine, 1984