Synthesis of novel 2-alkyl substituted oleobenzimidazole derivatives using ethylene glycol as solvent
- 1 November 2008
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 86 (11), 1030-1033
- https://doi.org/10.1139/v08-152
Abstract
The objective of this research was to conduct constructive organic chemistry by using ethylene glycol as an efficient solvent and to achieve yields that were comparable to or better than those in other media. The reaction parameters, such as temperature (150–200 °C), density, and reaction time (6 h), have been systematically studied to understand whether ethylene glycol is as an efficient solvent and can have a positive effect on the chemistry with good yields. By tuning the parameters, the yields have been optimized to around 70%-80%. Thus, a new class of 2-alkyl substituted oleo-benzimidazole derivatives have been synthesized and characterized by FTIR, 1H NMR, 13C NMR, MS, and elemental analysis.Key words: oleochemistry, ethylene glycol, oleo-benzimidazole derivatives, unusual fatty acids.Keywords
This publication has 8 references indexed in Scilit:
- The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged SubstructuresChemical Reviews, 2003
- CONDENSATION OFO-PHENYLENEDIAMINE WITH CINNAMIC ACIDSSynthetic Communications, 2001
- A New Class of Symmetric Bisbenzimidazole-Based DNA Minor Groove-Binding Agents Showing Antitumor ActivityJournal of Medicinal Chemistry, 2000
- Room-Temperature Ionic Liquids. Solvents for Synthesis and CatalysisChemical Reviews, 1999
- Model systems for type I copper proteins: structures of copper coordination compounds with thioether and azole-containing ligandsCoordination Chemistry Reviews, 1990
- Cobalt(II), nickel(II) and copper(II) complexes of bidentate bibenzimidazolesTransition Metal Chemistry, 1988
- Polyphosphate Esters as Synthetic Reagent. I. Synthesis of 2-Substituted BenzimidazolesCHEMICAL & PHARMACEUTICAL BULLETIN, 1964
- The Use of Polyphosphoric Acid in the Synthesis of 2-Aryl- and 2-Alkyl-substituted Benzimidazoles, Benzoxazoles and Benzothiazoles1Journal of the American Chemical Society, 1957