Impact of Intensive School-Based Nutrition Education and Lifestyle Interventions on Insulin Resistance, β-Cell Function, Disposition Index, and Subclinical Inflammation Among Asian Indian Adolescents: A Controlled Intervention Study
- 1 April 2011
- journal article
- Published by Mary Ann Liebert Inc in Metabolic Syndrome and Related Disorders
- Vol. 9 (2), 143-150
- https://doi.org/10.1089/met.2010.0094
Abstract
The present study was designed to assess the impact of intensive and repetitive nutrition education and lifestyle interventions on insulin resistance, β-cell function, disposition index (DI), and subclinical inflammation in Asian Indian adolescents (15-17 years) residing in North India. In this prospective study, two matched schools were randomly allocated to the intervention (n = 56; 31 boys and 25 girls) or control group (n = 50; 30 boys and 20 girls). The intervention consisted of seven components: (1) Dissemination of health-related information through lectures and focused group discussions, (2) planning of activities such as quizzes, (3) individual counseling of students, (4) promotion of physical activity, (5) change in the canteen menu to healthier alternatives, (6) conducting health camps involving parents and teachers, and (7) training of student volunteers for sustainability of the program in school. Impact of intervention was studied on surrogate markers of insulin resistance, β-cell function, disposition index, and subclinical inflammation. At 6 months follow-up, significantly higher (P = 0.037) mean value of homeostasis model assessment denoting β-cell function (HOMA-βCF) was seen in the intervention group compared to the control group, whereas high sensitivity C-reactive protein (hs-CRP) was significantly lowered (P < 0.001). The increase (30.3 ± 73.4; P < 0.037) observed in the DI in adolescents in the intervention group was significantly higher compared to the control group. The Pearson's coefficient of correlation in the intervention group showed that the Δ-decrease in mean waist circumference was significantly correlated (r = 0.267, P < 0.05) with Δ-decrease in homeostasis model assessment of insulin resistance (HOMA-IR). The intervention model developed by us could be used for amelioration of insulin resistance with potential of preventing type 2 diabetes mellitus in Asian Indian adolescents.This publication has 33 references indexed in Scilit:
- Secular Trends in Obesity, Regional Adiposity and Metabolic Parameters among Asian Indian Adolescents in North India: A Comparative Data Analysis of Two Selective Samples 5 Years Apart (2003, 2008)Annals of Nutrition and Metabolism, 2010
- Low-grade inflammation and the metabolic syndrome in children and adolescentsCurrent Opinion in Lipidology, 2008
- Metabolic complications of obesity in childhood and adolescence: more than just diabetesCurrent Opinion in Endocrinology, Diabetes and Obesity, 2008
- Metabolic syndrome in children: current issues and South Asian perspectiveNutrition, 2007
- High prevalence of insulin resistance in postpubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fatInternational Journal of Obesity, 2004
- C-reactive protein in young individuals: problems and implications for Asian IndiansNutrition, 2004
- Obesity in children and young people: a crisis in public healthObesity Reviews, 2004
- Correlations of C-reactive protein levels with anthropometric profile, percentage of body fat and lipids in healthy adolescents and young adults in urban North IndiaAtherosclerosis, 2003
- Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white childrenBMJ, 2002
- The role of insulin in clustering of serum lipids and blood pressure in children and adolescentsDiabetologia, 1995