Neutrophil extracellular traps: Is immunity the second function of chromatin?
Top Cited Papers
Open Access
- 3 September 2012
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 198 (5), 773-783
- https://doi.org/10.1083/jcb.201203170
Abstract
Neutrophil extracellular traps (NETs) are made of processed chromatin bound to granular and selected cytoplasmic proteins. NETs are released by white blood cells called neutrophils, maybe as a last resort, to control microbial infections. This release of chromatin is the result of a unique form of cell death, dubbed "NETosis." Here we review our understanding of how NETs are made, their function in infections and as danger signals, and their emerging importance in autoimmunity and coagulation.Keywords
This publication has 113 references indexed in Scilit:
- Neutrophil clearance: when the party is over, clean-up beginsTrends in Immunology, 2011
- Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modalityCell Death & Differentiation, 2011
- Neutrophil extracellular trap cell death requires both autophagy and superoxide generationCell Research, 2010
- Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular trapsThe Journal of cell biology, 2010
- Extracellular DNA traps promote thrombosisProceedings of the National Academy of Sciences of the United States of America, 2010
- Impairment of neutrophil extracellular trap degradation is associated with lupus nephritisProceedings of the National Academy of Sciences of the United States of America, 2010
- Extracellular histones are major mediators of death in sepsisNature Medicine, 2009
- Netting neutrophils in autoimmune small-vessel vasculitisNature Medicine, 2009
- Leishmania amazonensispromastigotes induce and are killed by neutrophil extracellular trapsProceedings of the National Academy of Sciences of the United States of America, 2009
- Novel cell death program leads to neutrophil extracellular trapsThe Journal of cell biology, 2007