Serial cine‐magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats
Open Access
- 31 October 2001
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 14 (5), 547-555
- https://doi.org/10.1002/jmri.1218
Abstract
The purpose of the present study was the serial investigation of morphological and functional changes after left coronary artery ligation in the intact rat using cine‐magnetic resonance imaging (MRI). MRI studies were performed 4, 8, 12, and 16 weeks after myocardial infarction (MI) with an echocardiogram (ECG)‐triggered cine‐fast low‐angle shot (FLASH)‐sequence in a 7‐Tesla magnet. MI‐size, left ventricular (LV) mass and volumes, cardiac index, ejection fraction (EF), and remote wall and scar thickness of 11 Wistar rats were compared to four sham‐operated rats. Stress MRI with dobutamine (10 μl/kg × minute) was performed at 16 weeks. In MI groups (small MI < 30%, N = 5, large MI > 30%, N = 6), there was significant increase of LV mass (small MI + 47.8% increase, large MI + 74.1%) and wall thickness (large MI 1.21 ± 0.03 to 1.84 ± 0.07 mm). Scar thickness declined from four to 16 weeks (large MI 0.92 ± 0.06 to 0.38 ± 0.02mm, P < 0.05). End‐diastolic volume of both MI groups was significantly elevated but increased further only in animals with large MI from four to 16 weeks (657.1 ± 38.6 to 869.7 ± 60.7 μL, P < 0.05). Compared to sham, EF was significantly depressed in MI (large MI 31.5 ± 2.0%). Wall thickening declined from four to 16 weeks post‐MI (large MI 50.9 ± 9.9 to 28.9 ± 4.4%, P < 0.05). During stress, sham and MI rats increased wall thickening from 66.5 ± 8.2 to 111.2 ± 6.7% and from 30.8 ± 4.3 to 47.5 ± 5.8%, respectively (P < 0.05). Hypertrophy was found in all animals with MI throughout the entire period of observation, whereas dilatation after four weeks was only detected in animals with large MI. These morphologic changes were accompanied by an early decline of EF; myocardial function characterized by wall thickening deteriorated later. J. Magn. Reson. Imaging 2001;14:547–555.Keywords
This publication has 30 references indexed in Scilit:
- In Vivo Assessment of Cardiac Remodeling After Myocardial Infarction in Rats by Cine-Magnetic Resonance ImagingJournal of Cardiovascular Magnetic Resonance, 2000
- Time Course of Spirapril-Induced Structural and Functional Changes After Myocardial Infarction in Rats Followed with Magnetic Resonance ImagingJournal of Cardiovascular Pharmacology, 1993
- Effect of cilazapril on regional left ventricular wall thickness and chamber dimension following acute myocardial infarction: In vivo assessment using MRIAmerican Heart Journal, 1992
- Serial changes in left ventricular size after acute myocardial infarctionThe American Journal of Cardiology, 1991
- Interstudy reproducibility of dimensional and functional measurements between cine magnetic resonance studies in the morphologically abnormal left ventricleAmerican Heart Journal, 1990
- The value of cine nuclear magnetic resonance imaging for assessing regional ventricular functionJournal of the American College of Cardiology, 1989
- Expansion of acute myocardial infarction: an experimental study.Circulation, 1982
- Prognosis after initial myocardial infarction: The Framingham studyThe American Journal of Cardiology, 1979
- Infarct expansion versus extension: Two different complications of acute myocardial infarctionThe American Journal of Cardiology, 1978
- Wall stress and patterns of hypertrophy in the human left ventricle.JCI Insight, 1975