Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates
Top Cited Papers
Open Access
- 13 March 2014
- Vol. 4 (3), e003901
- https://doi.org/10.1136/bmjopen-2013-003901
Abstract
Objectives To systematically review the literature pertaining to the prevalence of depression and anxiety in patients with prostate cancer as a function of treatment stage. Design Systematic review and meta-analysis. Participants 4494 patients with prostate cancer from primary research investigations. Primary outcome measure The prevalence of clinical depression and anxiety in patients with prostate cancer as a function of treatment stage. Results We identified 27 full journal articles that met the inclusion criteria for entry into the meta-analysis resulting in a pooled sample size of 4494 patients. The meta-analysis of prevalence rates identified pretreatment, on-treatment and post-treatment depression prevalences of 17.27% (95% CI 15.06% to 19.72%), 14.70% (95% CI 11.92% to 17.99%) and 18.44% (95% CI 15.18% to 22.22%), respectively. Pretreatment, on-treatment and post-treatment anxiety prevalences were 27.04% (95% CI 24.26% to 30.01%), 15.09% (95% CI 12.15% to 18.60%) and 18.49% (95% CI 13.81% to 24.31%), respectively. Conclusions Our findings suggest that the prevalence of depression and anxiety in men with prostate cancer, across the treatment spectrum, is relatively high. In light of the growing emphasis placed on cancer survivorship, we consider that further research within this area is warranted to ensure that psychological distress in patients with prostate cancer is not underdiagnosed and undertreated.This publication has 33 references indexed in Scilit:
- Evaluation of the association of prostate cancer‐specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancerPsycho‐Oncology, 2012
- Patient Anxiety About Prostate Cancer Independently Predicts Early Initiation of Androgen Deprivation Therapy for Biochemical Cancer Recurrence in Older Men: A Prospective Cohort StudyJournal of Clinical Oncology, 2009
- Does active surveillance for men with localized prostate cancer carry psychological morbidity?BJU International, 2007
- Prospective study of depression and fatigue in men with advanced prostate cancer receiving hormone therapyPsycho‐Oncology, 2007
- An analysis of the psychometric profile and frequency of anxiety and depression in Australian men with prostate cancerPsycho‐Oncology, 2006
- Do Patients With Localized Prostate Cancer Treatment Really Want More Aggressive Treatment?Journal of Clinical Oncology, 2006
- Anxiety and depression after prostate cancer diagnosis and treatment: 5-year follow-upBritish Journal of Cancer, 2006
- Psychological Functioning Associated with Prostate Cancer: Cross-Sectional Comparison of Patients Treated with Radiotherapy, Brachytherapy, or SurgeryJournal of Pain and Symptom Management, 2005
- Assessing the independent contribution to quality of life from anxiety and depression in patients with advanced cancerPalliative Medicine, 2003
- Depression in Men Receiving Androgen Deprivation Therapy for Prostate Cancer: A Pilot StudyPsycho‐Oncology, 2002