Gamma knife radiosurgery for central neurocytoma
Open Access
- 9 October 2007
- Vol. 110 (10), 2276-2284
- https://doi.org/10.1002/cncr.23036
Abstract
BACKGROUND. Little is known about long-term results of gamma knife (GK) stereotactic radiosurgery (SRS) as a primary or a secondary postoperative therapy for central neurocytomas (CNs). The authors retrospectively reviewed long-term outcomes of 13 patients with CN treated with GK SRS. METHODS. Thirteen patients were treated with GK SRS as a primary (6 patients) or a secondary postoperative therapy (7 patients). Follow-up clinical status and brain magnetic resonance imaging (MRI) were thoroughly analyzed. The functional status of patients was assessed with the Karnofsky Performance Scale during follow-up. RESULTS. The median follow-up period for clinical status and imaging studies was 61 months (range, 6 months to 96 months). Tumors decreased in 5 patients who received GK SRS as a primary treatment. However, the tumor recurred in 2 patients treated with a secondary GK SRS after surgery from the residual tumor bed that was not covered by the GK SRS. Parenchymal changes and secondary malignancies were not found in follow-up MRIs of all 13 patients. The Karnofsky Performance Scale score of all patients, except for 1 patient who suffered from an unrelated anteriorly communicating arterial aneurysmal rupture, did not change after GK SRS. CONCLUSIONS. GK SRS may be useful as a primary or a secondary postoperative therapy for the treatment of CN. However, more attention should be paid to residual or recurrent CN during treatment, and regular long-term follow-up MRI should be mandatory to validate the procedure. Cancer 2007 © 2007 American Cancer Society.This publication has 41 references indexed in Scilit:
- Less Common Indications for Stereotactic Radiosurgery or Fractionated Radiotherapy for Patients with Benign Brain TumorsNeurosurgery Clinics of North America, 2006
- Central neurocytoma: a novel appraisal of a polymorphic pathology Our experience and a review of the literatureNeurosurgical Review, 2006
- Recurrent central neurocytomasCancer, 2005
- Linear accelerator radiosurgery in treatment of central neurocytomasActa Neurochirurgica, 2003
- Radiosurgery for the Treatment of Recurrent Central NeurocytomasNeurosurgery, 2001
- Stereotactic Radiosurgery for Recurrent Central Neurocytoma: Case ReportNeurosurgery, 2001
- Central neurocytoma: Clinical, immunohistologic, and biologic findings of a human neuroglial progenitor tumorSurgical Neurology, 1996
- Central neurocytoma: Report of 2 cases and literature reviewJournal of Neuro-Oncology, 1993
- Bragg-Peak Proton-Beam Therapy for Arteriovenous Malformations of the BrainThe New England Journal of Medicine, 1983