Use of topical ocular antibiotics in young children: a Scandinavian drug utilization study
- 9 June 2018
- journal article
- research article
- Published by Wiley in Acta Ophthalmologica
- Vol. 96 (8), 789-794
- https://doi.org/10.1111/aos.13813
Abstract
Purpose Acute infectious conjunctivitis is a common disease. While usually self‐limiting, children often receive treatment to be accepted back into nursery, day care or school. We aimed to describe trends in the utilization of topical ocular antibiotics in young children aged 0–4 years in Denmark, Norway and Sweden. Methods Using individual‐level data from the Danish National Prescription Registry (2000–2015), we provided detailed descriptions of treatment patterns at the individual level, stratified by age (0–1 years, 2–4 years) and antibiotic substance. Aggregate‐level data for Danish, Norwegian and Swedish children (0–4 years) were obtained from publicly available data sources (2000–2016). Results We identified 107 581 Danish children aged 0–4 years receiving 271 980 treatment episodes. The incidence rate was relatively stable between 2000 and 2010 (on average, 637 and 283/1000 person‐years for 0‐ to 1‐ and 2‐ to 4‐year‐olds, respectively), after which it dropped by 37% until 2015. In the aggregated data, a markedly higher use was seen in Denmark (211/1000 children in 2016) compared with Sweden (42) and Norway (151). The decrease from 2010 onwards was observed in all three countries. Chloramphenicol and fusidic acid were the most commonly used topical ocular antibiotics across Scandinavia. Tobramycin was rarely used in Norway and Sweden (≤1/1000 children in 2016) compared with Denmark (24/1000 children). Conclusion Considerable variation is seen in the utilization of topical ocular antibiotics among children in Scandinavia, with Denmark having the highest use. Across the Scandinavian countries, however, a decline was noted from 2010 onwards.Funding Information
- Velux Fonden
- Fight for Sight
This publication has 20 references indexed in Scilit:
- Primary non-adherence in general practice: a Danish register studyEuropean Journal of Clinical Pharmacology, 2014
- ConjunctivitisJAMA, 2013
- The Nordic prescription databases as a resource for pharmacoepidemiological research—a literature reviewPharmacoepidemiology and Drug Safety, 2013
- Antibiotics versus placebo for acute bacterial conjunctivitisEmergencias, 2012
- Non-viral microbial keratitis in childrenSaudi Journal of Ophthalmology, 2011
- Acute bacterial conjunctivitisActa Ophthalmologica, 2008
- Do general practitioners adhere to the guideline on infectious conjunctivitis? Results of the Second Dutch National Survey of General PracticeBMC Family Practice, 2007
- A randomised controlled trial of management strategies for acute infective conjunctivitis in general practiceBMJ, 2006
- Why do General Practitioners prescribe antibiotics for acute infective conjunctivitis in children? Qualitative interviews with GPs and a questionnaire survey of parents and teachersFamily Practice, 2005
- Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: a randomised double-blind placebo-controlled trialThe Lancet, 2005