Lewis Base Catalyzed Stereo‐ and Regioselective Bromocyclization
- 4 October 2016
- journal article
- review article
- Published by Wiley in The Chemical Record
- Vol. 17 (3), 287-311
- https://doi.org/10.1002/tcr.201600088
Abstract
Oxygen- and nitrogen-containing heterocyclic compounds are widely recognized as key components in many natural products and biologically relevant molecules, but often the problem comes down to methodologies in synthesizing them. Halocyclization of olefinic substrates is a promising strategy in the construction of O- and N-heterocyclic compounds, which further signifies the development of their asymmetric variants. Over the past years, our group has been devoted to this particular area of asymmetric electrophilic halocyclization with chalcogen-containing molecules as catalysts. In this account, the main focus is on the development of our novel chiral catalysts and applications derived from the reaction products.Keywords
Funding Information
- Chinese University of Hong Kong Direct Grant (4053154, 4053157)
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