Multiple Release Kinetics of Targeted Drug from Gold Nanorod Embedded Polyelectrolyte Conjugates Induced by Near-Infrared Laser Irradiation
- 21 September 2010
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 132 (40), 14163-14171
- https://doi.org/10.1021/ja105360z
Abstract
The conjugates of gold nanorods and the model drug, fluorescein isothiocyanate (FITC), embedded inside polyelectrolytes (GNRs/FITC@PLE) were synthesized to study the release kinetics of FITC under femtosecond near-infrared (NIR) laser irradiation. The optical and structural properties of GNRs/FITC@PLE conjugates before and after laser treatments were examined using UV-vis spectroscopy, confocal microscopy, and transmission electron microscopy (TEM). The release of FITC from the conjugates was induced by the heat generated from gold nanorods under laser irradiation. The concentration of released FITC was measured as the time of continuous and periodic laser irradiation was varied. Within 5 min of the laser exposure, the release rates of FITC exhibited zero-order and first-order kinetics under continuous and periodic irradiation, respectively. Furthermore, a drug release system was designed based on the conjugates of gold nanorods and the anticancer drug, paclitaxel (PTX), embedded inside polyelectrolytes (GNRs/PTX@PLE). The conjugates were applied for in vitro studies with breast cancer cells. The release of PTX from the conjugates was triggered by NIR laser irradiation, and the inhibition rates of the cells showed strong dependencies on the irradiation modes and time. The results suggested that the multiple releases of PTX from the conjugates can be controlled by laser irradiation within a long period of time. Our system holds great potential for future therapeutic applications on breast cancers.This publication has 69 references indexed in Scilit:
- Spectrally Tunable Leakage-Free Gold NanocontainersJournal of the American Chemical Society, 2009
- Gold nanocages covered by smart polymers for controlled release with near-infrared lightNature Materials, 2009
- Controlling Affinity Binding with Peptide‐Functionalized Poly(ethylene glycol) HydrogelsAdvanced Functional Materials, 2009
- Thermal analysis of gold nanorods heated with femtosecond laser pulsesJournal of Physics D: Applied Physics, 2008
- Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of CancerJournal of the American Chemical Society, 2008
- Ligand-Directed Nanobialys as Theranostic Agent for Drug Delivery and Manganese-Based Magnetic Resonance Imaging of Vascular TargetsJournal of the American Chemical Society, 2008
- Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug DeliveryACS Nano, 2008
- Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug DesignJournal of the American Chemical Society, 2007
- Taxol induced apoptosis regulates amino acid transport in breast cancer cellsApoptosis, 2006
- Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agentMicroelectronic Engineering, 2006