Regulatory T Cells in Immunologic Self-Tolerance and Autoimmune Disease
- 1 January 2005
- journal article
- review article
- Published by Informa UK Limited in International Reviews of Immunology
- Vol. 24 (3-4), 211-226
- https://doi.org/10.1080/08830180590934976
Abstract
Naturally arising CD25+CD4+ regulatory T cells play key roles in the maintenance of immunologic self-tolerance and negative control of various immune responses. The majority, if not all, of them are produced by the normal thymus as a functionally distinct T-cell subpopulation, and their generation is in part developmentally controlled. Genetic abnormality in the development and function of this population can indeed be a cause of autoimmune disease, immunopathology, and allergy in humans. This regulatory population can be exploited to prevent and treat autoimmune disease by strengthening and reestablishing immunologic self-tolerance.Keywords
This publication has 42 references indexed in Scilit:
- Self-representation in the thymus: an extended viewNature Reviews Immunology, 2004
- NaturallyArisingCD4+RegulatoryT Cells forImmunologicSelf-Tolerance andNegativeControl ofImmuneResponsesAnnual Review of Immunology, 2004
- Evolving concepts of rheumatoid arthritisNature, 2003
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseNature, 2003
- Control of Regulatory T Cell Development by the Transcription Factor Foxp3Science, 2003
- The enemy within: keeping self-reactive T cells at bay in the peripheryNature Reviews Immunology, 2002
- Regulatory T Cells in AutoimmmunityAnnual Review of Immunology, 2000
- Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartmentImmunity, 1995
- Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.The Journal of Experimental Medicine, 1993
- Diabetes Mellitus and Autoimmunity in Patients with the Congenital Rubella SyndromeClinical Infectious Diseases, 1985