Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs
Open Access
- 5 April 2012
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 40 (14), 6391-6400
- https://doi.org/10.1093/nar/gks296
Abstract
The recent discovery that the human and other mammalian genomes produce thousands of long non-coding RNAs (lncRNAs) raises many fascinating questions. These mRNA-like molecules, which lack significant protein-coding capacity, have been implicated in a wide range of biological functions through diverse and as yet poorly understood molecular mechanisms. Despite some recent insights into how lncRNAs function in such diverse cellular processes as regulation of gene expression and assembly of cellular structures, by and large, the key questions regarding lncRNA mechanisms remain to be answered. In this review, we discuss recent advances in understanding the biology of lncRNAs and propose avenues of investigation that may lead to fundamental new insights into their functions and mechanisms of action. Finally, as numerous lncRNAs are dysregulated in human diseases and disorders, we also discuss potential roles for these molecules in human health.Keywords
This publication has 103 references indexed in Scilit:
- Xist regulation and function eXploredHuman Genetics, 2011
- A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 ResponseCell, 2010
- Long non-coding RNAs in nervous system function and diseaseBrain Research, 2010
- Evolution and Functions of Long Noncoding RNAsCell, 2009
- RNA regulation of epigenetic processesBioEssays, 2009
- Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAsCell, 2007
- High-Resolution Profiling of Histone Methylations in the Human GenomeCell, 2007
- Chromatin Modifications and Their FunctionCell, 2007
- A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem CellsCell, 2006
- Regulating Gene Expression through RNA Nuclear RetentionCell, 2005