Long-Range Reactive Dynamics in Myoglobin
- 21 May 2001
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 86 (21), 4966-4969
- https://doi.org/10.1103/physrevlett.86.4966
Abstract
We report the complete vibrational spectrum of the probe nucleus at the oxygen-binding site of the protein myoglobin. The Fe-pyrrole nitrogen stretching modes of the heme group, identified here, probe asymmetric interactions with the protein environment. Collective oscillations of the polypeptide, rather than localized heme vibrations, dominate the low frequency region. We conclude that the heme “doming” mode is significantly delocalized, so that distant sites respond to oxygen binding on vibrational time scales. This has ramifications for understanding long-range interactions in biomolecules, such as those that mediate cooperativity in allosteric proteins.
Keywords
This publication has 29 references indexed in Scilit:
- Investigations of Coherent Vibrational Oscillations in MyoglobinThe Journal of Physical Chemistry A, 2000
- Far-Infrared Emission by Boson Peak Vibrations in a Globular ProteinPhysical Review Letters, 1999
- Measurement and simulation of nuclear inelastic-scattering spectra of molecular crystalsPhysical Review B, 1999
- Observation of Coherent Reaction Dynamics in Heme ProteinsScience, 1994
- Direct Observation of Global Protein Motion in Hemoglobin and Myoglobin on Picosecond Time ScalesScience, 1991
- Far-infrared perturbation of reaction rates in myoglobin at low temperaturesPhysical Review Letters, 1989
- Conformational Substates in ProteinsAnnual Review of Biophysics and Biophysical Chemistry, 1988
- X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 Å resolutionJournal of Molecular Biology, 1986
- A consistent picture of protein dynamics.Proceedings of the National Academy of Sciences, 1984
- Evidence for Conformational and Diffusional Mean Square Displacements in Frozen Aqueous Solution of OxymyoglobinPhysical Review Letters, 1980