Multifarious roles of sialic acids in immunity
Top Cited Papers
- 23 April 2012
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1253 (1), 16-36
- https://doi.org/10.1111/j.1749-6632.2012.06517.x
Abstract
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with vertebrates. This overview surveys examples of biological roles of sialic acids in immunity, with emphasis on an evolutionary perspective. Given the breadth of the subject, the treatment of individual topics is brief. Subjects discussed include biophysical effects regulation of factor H; modulation of leukocyte trafficking via selectins; Siglecs in immune cell activation; sialic acids as ligands for microbes; impact of microbial and endogenous sialidases on immune cell responses; pathogen molecular mimicry of host sialic acids; Siglec recognition of sialylated pathogens; bacteriophage recognition of microbial sialic acids; polysialic acid modulation of immune cells; sialic acids as pathogen decoys or biological masks; modulation of immunity by sialic acid O‐acetylation; sialic acids as antigens and xeno‐autoantigens; antisialoglycan antibodies in reproductive incompatibility; and sialic‐acid–based blood groups.Keywords
This publication has 183 references indexed in Scilit:
- Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapyBiochemical Pharmacology, 2011
- Supramolecular Complexing of Membane Siglec CD22 Mediated by a Polyvalent Heterobifunctional Ligand that Templates on IgMBioconjugate Chemistry, 2011
- Multivalent Ligands for SiglecsMethods in Enzymology, 2010
- Functionally defective germline variants of sialic acid acetylesterase in autoimmunityNature, 2010
- CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patternsTrends in Immunology, 2009
- Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host‐cell recognitionFEBS Letters, 2009
- Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell toleranceTrends in Immunology, 2009
- Siglecs as targets for therapy in immune-cell-mediated diseaseTrends in Pharmacological Sciences, 2009
- Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxinNature, 2008
- Sialoside Analogue Arrays for Rapid Identification of High Affinity Siglec LigandsJournal of the American Chemical Society, 2008