REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
Open Access
- 7 June 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 41 (7), 820-823
- https://doi.org/10.1038/ng.395
Abstract
We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and 4,504 controls from North America and identified an association at the REL locus, encoding c-Rel, on chromosome 2p13 (rs13031237, P = 6.01 x 10(-10)). Replication in independent case-control datasets comprising 2,604 cases and 2,882 controls confirmed this association, yielding an allelic OR = 1.25 (P = 3.08 x 10(-14)) for marker rs13031237 and an allelic OR = 1.21 (P = 2.60 x 10(-11)) for marker rs13017599 in the combined dataset. The combined dataset also provides definitive support for associations at both CTLA4 (rs231735; OR = 0.85; P = 6.25 x 10(-9)) and BLK (rs2736340; OR = 1.19; P = 5.69 x 10(-9)). c-Rel is an NF-kappaB family member with distinct functional properties in hematopoietic cells, and its association with rheumatoid arthritis suggests disease pathways that involve other recently identified rheumatoid arthritis susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.Keywords
This publication has 30 references indexed in Scilit:
- Genetic risk factors for rheumatoid arthritis differ in caucasian and Korean populationsArthritis & Rheumatism, 2009
- Different patterns of associations with anti–citrullinated protein antibody–positive and anti–citrullinated protein antibody–negative rheumatoid arthritis in the extended major histocompatibility complex regionArthritis & Rheumatism, 2008
- Rheumatoid arthritis: a view of the current genetic landscapeGenes & Immunity, 2008
- Common 5p15.33 and 6p21.33 variants influence lung cancer riskNature Genetics, 2008
- Common variants at CD40 and other loci confer risk of rheumatoid arthritisNature Genetics, 2008
- Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13Nature Genetics, 2008
- Two independent alleles at 6q23 associated with risk of rheumatoid arthritisNature Genetics, 2007
- TRAF1–C5as a Risk Locus for Rheumatoid Arthritis — A Genomewide StudyThe New England Journal of Medicine, 2007
- Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphomaBlood, 2007
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988