Maturation of eukaryotic ribosomes: acquisition of functionality
- 4 February 2010
- journal article
- review article
- Published by Elsevier BV in Trends in Biochemical Sciences
- Vol. 35 (5), 260-266
- https://doi.org/10.1016/j.tibs.2010.01.001
Abstract
In eukaryotic cells, ribosomes are pre-assembled in the nucleus and exported to the cytoplasm where they undergo final maturation. This involves the release of trans-acting shuttling factors, transport factors, incorporation of the remaining ribosomal proteins, and final rRNA processing steps. Recent work, particularly on the large (60S) ribosomal subunit, has confirmed that the 60S subunit is exported from the nucleus in a functionally inactive state. Its arrival in the cytoplasm triggers events that render it translationally competent. Here we focus on these cytoplasmic maturation events and speculate why eukaryotic cells have evolved such an elaborate maturation pathway.Keywords
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