Clinical pharmacokinetic studies of a human haemopoietic growth factor, GM‐CSF
- 1 January 1992
- journal article
- clinical trial
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 22 (1), 45-49
- https://doi.org/10.1111/j.1365-2362.1992.tb01934.x
Abstract
The pharmacokinetics of glycosylated recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was studied following intravenous (i.v.) and subcutaneous (s.c.) bolus injection of rhGM-CSF, 8 micrograms kg-1 employing a sensitive radioimmunoassay. After a single i.v. bolus injection, an initial high serum level of rhGM-CSF was observed, followed by a rapid decrease that occurred in two phases with a half-life (t1/2) alpha of 20.0 +/- 5 min and a t1/2 beta of 68.3 +/- 8 min. Following s.c. bolus injection the absorption was more prolonged. Peak serum concentrations did not occur until about 15-20 h, and were followed by a more protracted elimination than by the i.v. route. In all patients the single rhGM-CSF injection led to an increase in peripheral white blood cells (WBC), after a temporary drop of 2-5 h duration. The increase in WBC was of longer duration after s.c. than after i.v. bolus treatment. Since the subcutaneous administration leads to prolonged serum concentration of rhGM-CSF and prolonged increase in peripheral WBC, it seems preferable to i.v. bolus injection, and as effective as continuous i.v. infusion.Keywords
This publication has 19 references indexed in Scilit:
- The effects of dose and route of the administration on the pharmacokinetics of granulocyte-macrophage colony-stimulating factorEuropean Journal of Cancer and Clinical Oncology, 1990
- Stimulation of Myelopoiesis in Patients with Aplastic Anemia by Recombinant Human Granulocyte-Macrophage Colony-Stimulating FactorNew England Journal of Medicine, 1988
- USE OF RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR IN THE BRAZIL RADIATION ACCIDENTThe Lancet, 1988
- Effects of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor in Patients with Myelodysplastic SyndromesNew England Journal of Medicine, 1987
- Effect of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor on Myelopoiesis in the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1987
- The Human Hematopoietic Colony-Stimulating FactorsScience, 1987
- Induction of Macrophage Tumoricidal Activity by Granulocyte-Macrophage Colony-Stimulating FactorScience, 1986
- Effects of N-linked Carbohydrate on the In Vivo Properties of Human GM-CSFCold Spring Harbor Symposia on Quantitative Biology, 1986
- The Granulocyte-Macrophage Colony-Stimulating FactorsScience, 1985
- Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant ProteinsScience, 1985