Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
Open Access
- 1 March 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 13 (3), 184-190
- https://doi.org/10.1038/ncb0311-184
Abstract
The ability to respond to perturbations in endoplasmic reticulum (ER) function is a fundamentally important property of all cells, but ER stress can also lead to apoptosis. In settings of chronic ER stress, the associated apoptosis may contribute to pathophysiological processes involved in a number of prevalent diseases, including neurodegenerative diseases, diabetes, atherosclerosis and renal disease. The molecular mechanisms linking ER stress to apoptosis are the topic of this review, with emphases on relevance to pathophysiology and integration and complementation among the various apoptotic pathways induced by ER stress.Keywords
This publication has 96 references indexed in Scilit:
- Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum StressCell Metabolism, 2010
- Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosisCell Death & Differentiation, 2010
- Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1Molecular Cell, 2010
- IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell FatesCell, 2009
- Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β CellsCell Metabolism, 2009
- Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOPCell Metabolism, 2009
- Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular BakThe EMBO Journal, 2009
- Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin ResistanceCell Metabolism, 2009
- Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA SplicingCell, 2008
- Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseCell, 1993